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1. This Agreement shall be open to signature by member States of the Council of Europe which take part in the activities in the field of public health referred to in Resolution (59) 23 mentioned in the Preamble hereto. They may become Parties to it by either:
a. signature without reservation in respect of ratification or acceptance, or
b. signature with reservation in respect of ratification or acceptance, followed by ratification or acceptance.
2. Instruments of ratification or acceptance shall be deposited with the Secretary General of the Council of Europe.